目的:探讨糖尿病前期中医体质分布规律,确定该病常见的高危体质类型,为今后的临床和科学研究提供循证证据.方法:检索国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)及中文科技期刊数据库(CCD)、PubMed、Embase、Cochrane Library、Web of Science数据库,纳入所有评价糖尿病前期与中医体质的相关性的临床研究文献.采用Strata 14.0软件进行横断面研究的单个率的Meta分析,Review Manager 5.3软件进行病例对照研究的Meta分析,用比值比(OR)和95％置信区间(CI)描述效应值.2位独立的评价者对纳入研究的方法学质量进行评估.结果:共纳入41项研究,样本量总计9 611例.痰湿质、平和质、阴虚质、气虚质分别占糖尿病前期人群的22％(18％～25％)、17％(13％～20％)、16％(13％～19％)和 11％(11％～15％).病例对照研究的Meta 分析显示,痰湿质、阴虚质人群糖尿病前期发病风险的OR值分别是2.86(1.84～4.45)和2.33(1.48～3.68).糖尿病前期人群在不同地区、年龄、性别方面,中医体质类型分布差异有统计学意义(P＜0.05).结论:痰湿质、平和质、阴虚质、气虚质是糖尿病前期人群最常见的体质,其中痰湿质、阴虚质可能是糖尿病前期发病的危险因素,平和质可能是糖尿病前期的保护因素.
Systematic Review and Meta-analysis on the Correlations between TCM Constitutions and Prediabetes
Objective:To investigate the distribution law of TCM constitutions in the patients with prediabetes and identify the common high-risk constitutions of prediabetes,so as to provide evidence for the future clinical practice and scientific research.Methods:The China National Knowledge Infrastructure(CNKI),China Biology Medicine(CBM),China Science Periodical Data-base(CSPD),Chinese Citation Database(CCD),PubMed,Embase,Cochrane Library,and Web of Science were searched for the ar-ticles about the clinical trials assessing the correlations between prediabetes and TCM constitutions.Strata 14.0 was used for meta-analysis of single rates in cross-sectional studies,and Review Manager 5.3 software was used for meta-analysis of case-control stud-ies.The odds ratio(OR)and 95％confidence interval(CI)were used to describe effect sizes.Two independent reviewers assessed the methodological quality of the included studies.Results:A total of 41 studies were included,with a total sample size of 9 611 pa-tients.Among the patients with prediabetes,those with phlegm-dampness,plain,yin deficiency,and qi deficiency constitutions ac-counted for 22％(18％to 25％),17％(13％to 20％),16％(13％to 19％),and 11％(11％to 15％),respectively.The meta-a-nalysis of the case-control studies showed that the OR values of the risk of prediabetes in the people with phlegm-dampness and yin-deficiency constitutions were 2.86(1.84 to 4.45)and 2.33(1.48 to 3.68),respectively.The distribution of TCM constitutions showcased significant differences in terms of different regions,ages,and genders(P＜0.05).Conclusion:Phlegm-dampness,plain,yin deficiency,and qi deficiency were the common TCM constitutions of the patients with prediabetes.Phlegm-dampness and yin de-ficiency constitutions may be the risk factors of prediabetes,and the plain constitution may be a protective factor of prediabetes.
国家科技期刊平台
NSTL
万方数据
