中药调控自噬干预高血压肾病研究进展
Research Progress of TCM Regulating Autophagy in Hypertensive Nephropathy
方震 1罗玉 1蔺晓源 2地娜拉·加力肯 1冯佳宁 3方祝元1
作者信息
- 1. 南京中医药大学附属医院,南京,210029
- 2. 湖南中医药大学第一附属医院,长沙,410007
- 3. 大连医科大学,大连,116000
- 折叠
摘要
肾脏是高血压并发症的重要靶器官之一,临床上高血压肾病患者的血压常常难以控制、病情迁延不愈,严重危害患者的生命质量.自噬是维持细胞稳态的机制之一,是高度分化细胞的一种自我清理方式,以清除不必要的蛋白质等细胞内成分,自噬过度及自噬抑制均会导致不同程度的细胞损伤.自噬在高血压肾病中的发病机制,主要涉及足细胞、内皮细胞等的自噬水平,以及中药通过影响自噬水平以治疗高血压肾病.
Abstract
The kidney is one of the main target organs of the complications of hypertension.The difficult control of blood pressure and the lingering symptoms affect the quality of life of the patients with hypertensive nephropathy.Autophagy,one of the mecha-nisms for maintaining cell homeostasis,is a self-cleaning way for highly differentiated cells to remove unnecessary intracellular com-ponents such as proteins.Excessive and inhibited autophagy can lead to cell damage in different degrees.This article summarizes the pathogenesis of autophagy in hypertensive nephropathy,mainly involving in the autophagy of podocytes and endothelial cells,and reviews the research progress in TCM treatment of hypertensive nephropathy via regulating autophagy.
关键词
自噬/高血压肾病/作用机制/中医药/阴阳理论/足细胞/内皮细胞/综述Key words
Autophagy/Hypertensive nephropathy/Mechanism/TCM/Yin-yang theory/Podocytes/Endothelial cells/Review引用本文复制引用
基金项目
国家自然科学基金面上项目(81873258)
江苏省自然科学基金面上项目(BK20201498)
出版年
2024
国家科技期刊平台
NSTL
万方数据