首页|丹白颗粒治疗盆腔炎性疾病后遗症的成本-效果分析

丹白颗粒治疗盆腔炎性疾病后遗症的成本-效果分析

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原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的:利用TreeAge Pro软件构建丹白颗粒治疗盆腔炎性疾病后遗症的决策树模型,对丹白颗粒对比抗生素干预盆腔炎性疾病后遗症的经济学进行分析,以期为临床药物选择提供一定依据.方法:成本参数来源于药智网数据库和相关公开发表的数据.效果参数基于一项前瞻性真实世界队列研究得出,评价2种治疗方案的短期成本-效果,模型模拟时间跨度14 d.利用倾向性评分匹配(PSM)法匹配,使2组基线可比.通过基础分析,敏感性分析,包括单因素敏感性分析(旋风图)、概率敏感性分析(成本-效果可接受曲线、增量成本效果散点图),对研究结果的稳健性进行验证.结果:基础分析结果显示,2组的增量成本效果比(ICER)为293.48元,与抗生素常规方案治疗比较,使用丹白颗粒治疗盆腔炎性疾病后遗症患者中每多降低1个中医证候评分需多支付293.48元.结论:在以2021年人均可支配收入作为意愿支付阈值的情况下,丹白颗粒治疗比常规抗生素治疗更具有经济学.当患者意愿支付阈值越高,丹白颗粒治疗可获得更高经济性.该结果与基础分析的ICER结果相近,ICER具有较好的稳健性.
Cost-efficacy Analysis of Danbai Granules in Treatment of Sequelae of Pelvic Inflammatory Disease
Objective:TreeAge Pro software was used to build a decision tree model of Danbai Granules in the treatment of sequel-ae of pelvic inflammatory diseases,and the economy of Danbai Granules and antibiotics in the treatment of sequelae of pelvic in-flammatory diseases was analyzed,so as to provide a certain basis for clinical drug selection.Methods:The cost parameters of this study were derived from the Pharmacointelligence database and related published data,and efficacy parameters were derived from a prospective real-world cohort study,so as to evaluate the short-term cost-efficacy of two treatment regiments after a 14-day model simulation.Propensity score matching(PSM)method was used to make the two groups of baseline comparable.The robustness of the research results was verified by basic analysis and sensitivity analysis,including single factor sensitivity analysis(cyclone map)and probabilistic sensitivity analysis(cost-efficacy acceptability curve and incremental cost-efficacy scatter plot).Results:The basic analysis results showed that the incremental cost-efficacy ratio(ICER)of the two groups was 293.48 yuan.Compared with the con-ventional antibiotic regimen,Danbai Granules required an additional payment of 293.48 yuan for reducing each TCM symptom score in the treatment of sequelae of pelvic inflammatory disease.Conclusion:In the case of 2021 per capita disposable income as the willing payment threshold,treatment with Danbai Granules is more economical than conventional antibiotic treatment.A higher willing payment threshold of patients indicates that treatment with Danbai Granules can be more economical.This result is similar to the ICER result of basic analysis,and ICER has good robustness.

Danbai GranulesAntibioticsReal-world studySequelae of pelvic inflammatory diseasePropensity scoreCost-ef-ficacy analysisTreeAge Pro softwareDecision tree model

杨绚如、薛晓鸥、朱玉莹、张志航

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北京中医药大学东直门医院,北京,100700

北京和平里医院,北京,100700

丹白颗粒 抗生素 真实世界研究 盆腔炎性疾病后遗症 倾向性评分 成本-效果分析 TreeAge Pro软件 决策树模型

国家重点研发计划项目

2018YFC1704106

2024

10.3969/j.issn.1673-7202.2024.12.018

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(12)