基于脑-肠轴理论的便秘型肠易激综合征伴焦虑抑郁中西医认识述要
Understanding of Constipation-predominant Irritable Bowel Syndrome with Anxiety and Depression Based on Brain-gut Axis Theory from Traditional Chinese and Western Medicine Perspectives
邹欣甫 1王得昌 1邹欣妍 2王康锋 3陈泽涛3
作者信息
- 1. 山东中医药大学第一临床医学院,济南,250014
- 2. 河北大学中医学院,保定,071030
- 3. 山东省中医院,济南,250014
- 折叠
摘要
随着西医学的研究和进展,多数医家认为精神心理状态与便秘型肠易激综合征(IBS-C)二者之间有着明确的联系.脑肠轴在二者的发病机制中皆处于重要的地位,以脑肠互动理论来论治本病已经受到了广泛的关注.西医认为脑-肠肽、肠道菌群失调等因素可导致肠易激综合征腹痛、精神心理状态改变等症状,中医上则多把脑-肠轴理论与中医各证型特点相关联.因此,以脑-肠轴为基点从脑-肠肽、肠道微生物、下丘脑-垂体-肾上腺(HPA)轴、心理因素、中医药治疗方面综述IBS-C伴焦虑抑郁状态的发病机制,为同行在临床的诊疗中提供新的思路.
Abstract
With the research and advancements in Western medicine,most medical experts believe that there is a clear link be-tween the psychological state and constipation-predominant irritable bowel syndrome(IBS-C).The brain-gut axis plays a crucial role in the pathogenesis of both conditions,and the use of brain-gut interaction theory for treating this disease has received wide-spread attention.According to Western medicine,factors such as brain-gut peptides and imbalances in gut microbiota can lead to symptoms of IBS-C,including abdominal pain and changes in mental and psychological state.Traditional Chinese medicine(TCM)often associates the brain-gut axis theory with different TCM syndrome types.This article reviewed the pathogenesis of IBS-C with anxiety and depression from the perspective of the brain-gut axis,focusing on brain-gut peptides,gut microbiota,hypothalamic-pitui-tary-adrenal(HPA)axis,psychological factors,and TCM treatment,so as to offer new insights to clinicians for the diagnosis and treatment of this condition.
关键词
脑-肠轴/肠道菌群/焦虑/抑郁/心理因素/便秘型肠易激综合征/心/肝/脾Key words
Brain-gut axis/Gut microbiota/Anxiety/Depression/Psychological factors/Constipation-predominant irritable bowel syndrome/Heart/Liver/Spleen引用本文复制引用
基金项目
国家自然基金青年科学基金项目(81303028)
山东省自然科学基金项目(ZR2020MH354)
出版年
2024
国家科技期刊平台
NSTL
万方数据