Effects of Water Extract from Cichorium intybus L.Root on Serum Glucose,Lipid,and Uric Acid Metabolism in Normal Rats and Liver and Kidney Safety
Objective:To observe the effects of water extract of Cichorium intybus L.on glucose,lipid,and uric acid metabolism,as well as liver and kidney safety in normal rats.Methods:SD rats were randomly divided into a blank control group(water by gavage),high-dose,medium-dose,and low-dose C.intybus L.groups(10,5,and 2.5 mg/kg),and a allopurinol group(20 mg/kg allopurinol so-lution).These treatments were conducted via gavage for 28 consecutive days.Dynamic measurements of serum glucose(GLU),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),ser-um uric acid(SUA),urinary uric acid(UUA),and fecal uric acid(FUA)levels were taken.Uric acid clearance rate(CUUA)and 12-hour urinary uric acid excretion were calculated.Enzyme levels in serum related to uric acid metabolism,such as xanthine oxidase(XOD)and adenosine deaminase(ADA),were also measured.Liver and kidney function indicators,including alanine aminotrans-ferase(GPT),aspartate aminotransferase(GOT),blood urea nitrogen(BUN),and creatinine(Cr),were evaluated,and liver and kid-ney indices were calculated.Results:During the experimental period,there were no significant differences between the C.intybus L.groups and the blank control group in terms of glucose,lipid,and uric acid metabolism indicators(GLU,TC,TG,HDL-C,LDL-C,SUA,XOD,ADA,UUA,FUA levels,CUUA,and 12-hour urinary uric acid excretion).Additionally,there were no significant differ-ences in liver and kidney safety indicators(GPT,GOT,BUN,Cr,liver index,and kidney index)among the groups.Conclusion:C.inty-bus L.root water extract does not affect glucose,lipid,or uric acid metabolism in normal rats and exhibits good liver and kidney safety.
Cichorium intybus L.root water extractNormal ratsSerum glucose,Glucose metabolismLipid metabolismUric acid metabolismLiver and kidney safety
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