首页|桂枝附子汤的临床应用和作用机制研究

桂枝附子汤的临床应用和作用机制研究

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桂枝附子汤出自《伤寒论》和《金匮要略》原文,桂枝附子汤证的核心病机是风湿搏结、正虚邪壅,其主要临床症状为身体烦疼、活动障碍,而祛风散寒、除湿止痛是桂枝附子汤的主要治疗方义.桂枝附子汤具祛风除湿、温阳散寒、通痹止痛之效,是中医治疗痹病的经典方剂,现代临床广泛应用于类风湿关节炎、痛风性关节炎、坐骨神经痛、肩周炎、神经根型颈椎病等疾病的治疗,疗效确切.桂枝附子汤的现代药理学作用机制可能与抗炎镇痛、调节免疫、改善关节症状等密切相关.
Clinical Application and Mechanism of Action of Guizhi Fuzi Decoction
Guizhi Fuzi Decoction,derived from Treatise on Cold Damage(Shang Han Lun)and Synopsis of the Golden Chamber(Jin Gui Yao Lue),addresses the syndromes with core pathogenesis of wind-dampness obstruction and healthy qi deficiency with pathogen retention.The main indicated clinical symptoms include generalized pain and restricted movement.The primary therapeu-tic principles of Guizhi Fuzi Decoction are to dispel wind,dissipate cold,eliminate dampness,and relieve pain.Guizhi Fuzi Decoc-tion,known for its effects of expelling wind,eliminating dampness,warming yang,dissipating cold,and unblocking obstructions to alleviate pain,is a classic prescription in traditional Chinese medicine(TCM)for treating impediment diseases.In modern clinical practice,Guizhi Fuzi Decoction is widely used to treat conditions such as rheumatoid arthritis,gouty arthritis,sciatica,frozen shoul-der,and radicular cervical spondylosis,with definite efficacy.The pharmacological mechanisms underlying the therapeutic effects of Guizhi Fuzi Decoction may be closely related to its anti-inflammatory and analgesic properties,immune regulation,and improvement of joint symptoms.

Guizhi Fuzi DecoctionTreatise on Cold DamageImpediment diseasesCore pathogenesisClinical symptomTreat-ment principlesClinical applicationMechanism of action

姜玉华、张冰晗、雷晶晶、荆业腾、刘继法、杨金生

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中国中医科学院中医基础理论研究所,北京,100700

桂枝附子汤 《伤寒论》 痹病 核心病机 临床症状 治疗方义 临床应用 作用机制

国家自然科学基金项目中国中医科学院科技创新工程项目中国中医科学院中医基础理论研究所自主选题项目

82074563CI2021A00104YZX-202247

2024

10.3969/j.issn.1673-7202.2024.13.016

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(13)
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