Effect of Zishen Yutai Pills Combined with Drotaverine Hydrochloride Tablets in the Treatment of Subchorionic Haematoma
Objective:To investigate the clinical effect of Zishen Yutai Pills combined with drotaverine hydrochloride tablets in the treatment of subchorionic haematoma(SCH)and to observe the expression levels of regulatory T cells(Treg)and T helper 17 cells(Th17)before and after treatment.Methods:From January 2023 to December 2023,97 patients with early threatened abortion combined with SCH,accompanied by lower abdominal pain and vaginal bleeding,were enrolled from the First Affiliated Hospital of Xinjiang Medical University.The patients were randomly divided into an observation group(n=47)and a control group(n=50)u-sing a random number table method.The control group received drotaverine hydrochloride treatment alone,while the observation group received Zishen Yutai Pills in addition to drotaverine hydrochloride.The general clinical data,clinical treatment efficacy,he-mostasis and pain relief indicators,ultrasound detection results of SCH,and peripheral blood Treg/Th17 expression levels before and after treatment were compared between the two groups.Results:After treatment,the SCH area to gestational sac area ratio was lower in both groups compared to those before treatment(P＜0.01),and the observation group was lower than the control group(P＜0.01).The hemostasis control time was shorter in the observation group than in the control group(P＜0.01).The clinical treatment efficacy rate was higher in the observation group than in the control group(P＜0.05).After treatment,TGF-β levels were higher and IL-17 levels were lower in both groups compared to those before treatment(P＜0.01).The observation group had higher TGF-β levels and lower IL-17 levels than the control group after treatment(P＜0.01).Conclusion:Zishen Yutai Pills combined with drotaverine hydrochloride tablets have a significant clinical effect in patients with early pregnancy SCH,which can improve the clinical treatment efficacy and promote the conversion of T cells to Treg cells.
万方数据
维普
