Effect of Jiawei Shengjiang Powder on Renal Tubule Function of Patients with Early Diabetic Nephropathy
Objective:To observe the effect and mechanism of Jiawei Shengjiang Powder on renal tubule function in patients with early diabetic nephropathy(DN).Methods:Ninety-two inpatients and outpatients with early DN,diagnosed with deficiency of both qi and yin and retention of turbid toxin and heat syndrome,were selected from the Nephropathy Department of Hebei Provincial Hospital of Traditional Chinese Medicine between March 2018 and October 2019.They were randomly divided into a control group and an observation group by simple randomization,with 46 patients in each group.The control group received standard treatment,while the observation group received Jiawei Shengjiang Powder in addition to standard treatment.The treatment period for both groups was two months.Traditional Chinese medicine(TCM)syndrome scores,clinical indicators[hemoglobin A1C(HbA1c),low density lipoprotein(LDL),total cholesterol(TC),urinary albumin excretion rate(UAER),glomerular filtration rate(GFR)],renal tubule function markers[α1-microglobulin(α1-MG),β2-microglobulin(β2-MG),liver fatty acid-binding protein(L-FABP)],and oxidative stress indicators[NADPH oxidase 4(NOX4),superoxide dismutase(SOD),total antioxidant capacity(T-AOC)]were re-corded before and after treatment in both groups.Results:After treatment,the overall efficacy rate was 92.68%in the observation group and 81.40%in the control group,showing a statistically significant difference(P<0.05).TCM syndrome scores,HbA1c,TC,LDL,and UAER decreased in both groups,with more significant reductions in the observation group(all P<0.05).There was no significant change in GFR in either group.Levels of α1-MG,β2-MG,and L-FABP decreased in both groups,with more signifi-cant reductions in the observation group(all P<0.05).NOX4 expression was suppressed,and T-AOC and SOD levels increased in both groups(all P<0.05),with more significant changes in the observation group(P<0.05).No adverse reactions were observed in either group.Conclusion:Jiawei Shengjiang Powder can improve clinical symptoms in patients with early DN,regulate the imbal-ance between oxidation and antioxidation,reduce oxidative stress,and alleviate renal tubule damage.
Jiawei Shengjiang PowderDiabetic nephropathyQi and yin deficiency,turbid toxin and heat stagnation syndromeRenal tubule injuryOxidative stressUAERTCM syndrome scoreImbalance between oxidation and antioxidation