基于肿瘤微环境力学应答-免疫调控论"虚郁致癌"病机观
Pathogenesis of Deficiency and Depression Causing Cancer Based on Mechanical Response-immune Regulation of Tumor Microenvironment
马苏苏 1高劲 1杜炎远 1蔡柳 2郑红刚3
作者信息
- 1. 中国中医科学院广安门医院,北京,100053
- 2. 陕西中医药大学,咸阳,712000
- 3. 中国中医科学院广安门医院,北京,100053;陕西中医药大学,咸阳,712000
- 折叠
摘要
虚、郁是恶性肿瘤发生发展的核心病因病机,间质高压、基质刚度增加等力学微环境特点与中医气郁病机状态相似,而力学应答引起的酸性代谢产物积累、低氧、慢性炎症的特点与中医"气郁"所致痰凝、血瘀、化火的病机相似,免疫抑制的生化微环境特点与中医"正虚"的病机相似.应用扶正、调气治法可逆转肿瘤微环境.中医药遵从整体观念、辨证论治的宏观诊疗思维,对局部微观环境的阴阳平衡、稳态调节也同样具有积极影响.
Abstract
Deficiency and depression are core pathogenic mechanisms in the occurrence and development of malignant tumors.Characteristics of the mechanical microenvironment,such as increased interstitial pressure and matrix stiffness,are similar to the traditional Chinese medicine(TCM)pathogenesis of qi depression.Mechanical responses that lead to the accumulation of acidic metabolic products,hypoxia,and chronic inflammation align with the TCM pathogenesis of phlegm coagulation,blood stasis,and fire transformation due to qi depression.The biochemical microenvironment of immunosuppression corresponds to the TCM concept of deficiency of vital energy.Applying the TCM therapeutic principles of supporting vital energy and regulating qi can reverse the tumor microenvironment.TCM,with its holistic view and treatment based on syndrome differentiation,not only align with the macro-scopic aspects of diagnosis and treatment but also positively affects the balance of yin and yang and homeostasis in the local micro-environment.
关键词
中医/肿瘤/虚郁致癌/病机/肿瘤微环境/生物力学/免疫调控/机制Key words
Traditional Chinese medicine/Tumor/Cancer caused by deficiency and depression/Pathogenesis/Tumor microenvi-ronment/Biomechanics/Immune regulation/Mechanism引用本文复制引用
基金项目
国家自然科学基金面上项目(82174463)
中央高水平中医医院临床研究和成果转化能力提升项目-传承名老中医药专家学术经验专项(HLCMHPP2023007)
出版年
2024
国家科技期刊平台
NSTL
万方数据