从胆汁酸代谢阐释肝脾失调在痰湿体质易发代谢紊乱中的作用机制
Mechanism of Liver-spleen Disharmony in Inducing Metabolic Diseases in Phlegm-dampness Constitution from the Perspective of Bile Acid Metabolism
吴玉琦 1张安琪 1万瑾毅 1姚海强1
作者信息
摘要
肝脾失调是常见的中医临床证候之一,表现为脾主运化和肝主疏泄失调,影响机体水液代谢,造成痰湿内蕴等代谢异常,是痰湿"体-病"转变的重要病机之一.胆汁酸参与机体的肝肠循环,对人体的糖脂代谢具有广泛的调控作用.通过从微观层面探讨胆汁酸作为中医"肝脾失调"理论的物质基础,揭示胆汁酸代谢与肝脾失调的科学内涵,力图从新的角度为痰湿体质易发代谢紊乱的病机提供科学阐释.此外,通过中药调节胆汁酸谱作为干预方式,可有效改善痰湿体质诱发的代谢紊乱,拓展中医痰湿体质研究的广度和深度,为痰湿临床调体提供新的研究思路和干预靶点.
Abstract
Liver-spleen disharmony is a common clinical syndrome in traditional Chinese medicine(TCM),characterized by the dysfunction of the spleen in transportation and transformation and the liver in free flow of qi,which affects the body's water metabo-lism and leads to metabolic abnormalities such as the accumulation of phlegm and dampness.It is a key pathogenesis in the transi-tion from a phlegm-dampness constitution to disease.Bile acids play a role in the enterohepatic circulation and have extensive regu-latory effects on glucose and lipid metabolism in the body.By the investigation of bile acids as the material basis for the TCM theory of liver-spleen disharmony at a microscopic level,the scientific connotation of bile acid metabolism and liver-spleen disharmony can be revealed.This approach aims to provide a scientific explanation for the pathogenesis of metabolic disorders in individuals with a phlegm-dampness constitution from a new perspective.Moreover,regulating the bile acid profile through Chinese medicine can ef-fectively improve the metabolic disorders induced by a phlegm-dampness constitution.This study expands the breadth and depth of TCM research on phlegm-dampness constitutions and provides new research directions and intervention targets for clinical regulation of phlegm-dampness.
关键词
胆汁酸/肝脾失调/痰湿体质/糖脂代谢/肝肠循环/代谢紊乱Key words
Bile acids/Liver-spleen disharmony/Phlegm-dampness constitution/Glycolipid metabolism/Enterohepatic circula-tion/Metabolic disorder引用本文复制引用
基金项目
国家自然科学基金项目(82274379)
中华中医药学会"青年人才托举工程"项目(CACM-2019-QNRC2-A01)
中央高校基本科研业务费专项(2020-JYB-XJSJJ-003)
出版年
2024
国家科技期刊平台
NSTL
万方数据