益肾调气法治疗肾虚肝郁型抑郁障碍远期复发率的多中心前瞻性队列研究

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国家科技期刊平台
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中文摘要：目的:评价益肾调气法对肾虚肝郁型抑郁障碍2年复发率的影响.方法:选取2017年1月至2018年4月在全国13个分中心招募肾虚肝郁型抑郁障碍患者,按照接受的治疗方案自然形成中医组、中西医组和西医组,比较3组的复发率.并根据干预的时间,将中医组和中西医组分为低、中、高3个暴露水平,比较不同水平的复发率,评价益肾调气法降低肾虚肝郁型抑郁障碍的远期复发率的效果.结果:共纳入肾虚肝郁型抑郁障碍1 314例,其中中医组385例,西医组453例,中西医组476例.中医组、西医组、中西医组的两年复发率分别是23.61％,34.97％、18.14％.中医组比西医组使复发风险降低29.2％(P＜0.05),中西医组比西医组使复发风险降低45.5％(P＜0.001).中医组以低中药水平暴露时间(TCM-ET)为参照,高TCM-ET较于低TCM-ET复发风险降低81.4％(P＜0.01);中西医组以低TCM-ET为参照,中TCM-ET比低TCM-ET复发风险降低46.9％(P＜0.05),高TCM-ET比低TCM-ET复发风险降低65.3％(P＜0.01).结论:益肾调气法治疗肾虚肝郁型抑郁障碍能够降低远期复发率,且中医药干预的暴露水平与复发率之间具有密切的关系,较长的暴露水平显著降低了患者的复发率.

外文标题：Long-term Recurrence Rate of Depressive Disorder with Kidney Deficiency and Liver Depression Syndrome by Kidney-tonifying and Qi-regulating Therapy:A Multi-centered,Prospective Cohort Study

外文摘要：Objective:To evaluate the effect of kidney-tonifying and qi-regulating therapy on the 2-year recurrence rate of depres-sive disorder with kidney deficiency and liver depression syndrome.Methods:Patients with depressive disorder characterized by kidney deficiency and liver depression syndrome were recruited from 13 sub-centers in China between January 2017 and April 2018.According to the treatment they received,patients were naturally divided into a traditional Chinese medicine(TCM)group,an integrated TCM and Western medicine group,and a Western Medicine group.The recurrence rates of the three groups were com-pared.Additionally,based on the duration of intervention,the TCM and integrated groups were divided into low,medium,and high exposure levels,and the recurrence rates at different levels were compared to evaluate the long-term effect of the kidney-tonifying and qi-regulating therapy in reducing the recurrence rate of depressive disorder with kidney deficiency and liver depression syn-drome.Results:A total of 1 314 patients with depressive disorder characterized by kidney deficiency and liver depression syndrome were included,with 385 in the TCM group,453 in the Western medicine group,and 476 in the integrated group.The 2-year recur-rence rates for the TCM,Western medicine,and integrated groups were 23.61％,34.97％,and 18.14％,respectively.The TCM group had a 29.2％lower risk of recurrence compared to the Western medicine group(P＜0.05),and the integrated group had a 45.5％lower risk of recurrence compared to the Western medicine group(P＜0.001).Using low TCM exposure time(TCM-ET)as a reference in the TCM group,high TCM-ET significantly reduced the risk of recurrence by 81.4％(P＜0.01).In the integrated group,compared to low TCM-ET,medium TCM-ET reduced the risk of recurrence by 46.9％(P＜0.05),and high TCM-ET re-duced the risk by 65.3％(P＜0.01).Conclusion:Kidney-tonifying and qi-regulating therapy can reduce the long-term recurrence rate of depressive disorder with kidney deficiency and liver depression syndrome.There is a close relationship between the level of TCM intervention exposure and the recurrence rate,with longer exposure levels significantly reducing the recurrence rate.

外文关键词：

Recurrence rateKidney-tonifying and qi-regulating therapyDepressive disorderYinao Jieyu FormulaProspectiveCohort studyMultiple centersMulti-factor regression analysis

作者：

叶橙、孙文军、唐启盛、黄世敬、王娣、郑军然、李小黎、尹洪娜、刘向哲、李乐军、王志强、徐向青、杨文明、林安基、马良、曲淼

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作者单位：

首都医科大学宣武医院,北京,100053

北京中医药大学第三附属医院,北京,100029

中国中医科学院广安门医院,北京,100053

首都医科大学附属北京安定医院,北京,100088

北京回龙观医院,北京,100096

黑龙江中医药大学附属第二医院,长春,130021

河南中医药大学第一附属医院,郑州,450000

南京中医院大学附属苏州医院,苏州,215003

清华大学附属北京市垂杨柳医院,北京,100022

山东中医药大学附属医院,济南,250011

安徽中医药大学第一附属医院,合肥,230031

北京中医药大学厦门医院,厦门,361001

北京市朝阳区第三医院,北京,100025

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关键词：

复发率益肾调气法抑郁障碍颐脑解郁方前瞻性队列研究多中心多因素回归分析

基金：

国家重点研发计划项目国家重点研发计划项目国家中医药行业专项

项目编号：

2020YFC20031002020YFC2003103201507001-12

出版年：

2024

DOI：

10.3969/j.issn.1673-7202.2024.15.016

世界中医药

世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心

影响因子：1.266

ISSN：1673-7202

年,卷(期)：2024.19(15)