基于骨免疫学论中医药抑制类风湿关节炎骨破坏的研究进展
Traditional Chinese Medicine in Inhibiting Bone Destruction in Rheumatoid Arthritis Based on Bone Immunology Theory:A Review
夏璇 1陈杰君 1张磊 2王茂杰 1黄闰月 1储永良2
作者信息
- 1. 广州中医药大学第二附属医院/广东省中医院,广州,510120
- 2. 广州中医药大学第二附属医院/广东省中医院,广州,510120;广东省中医院珠海医院,珠海,519015
- 折叠
摘要
类风湿关节炎(RA)是一种以滑膜炎、软骨与骨破坏为主要病理表现的自身免疫性疾病,致残率较高.RA免疫及炎症反应与骨细胞代谢互为影响,其核心环节为破坏机体核因子κB受体活化因子配体/核因子κB受体活化因子/骨保护素(RANKL/RANK/OPG)信号通路的平衡,导致成骨细胞减少,以及破骨细胞凋亡减退及异常活化.西药目前以抑制炎症反应及相关细胞因子分泌,减缓疾病进展,但长期使用其不良反应难以忽视.中医药在防治骨破坏中研究逐步深入,但在基础及临床研究方面仍存在一定局限性.
Abstract
Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis,cartilage,and bone destruction,with a high rate of disability.The immune and inflammatory responses in RA interact with bone cell metabolism,with a key mechanism in-volving the imbalance in the receptor activator of nuclear factor-κB ligand(RANKL)/RANK/osteoprotegerin(OPG)signaling path-way.This imbalance leads to decreased osteoblasts and increased osteoclast apoptosis and abnormal activation.While western medi-cine primarily focuses on inhibiting inflammatory responses and related cytokine secretion to slow disease progression,long-term use is associated with notable adverse effects.Research into traditional Chinese medicine(TCM)for preventing and treating bone de-struction in RA has advanced,but both basic and clinical research still face certain limitations.
关键词
骨免疫学/中医药/类风湿关节炎/骨破坏/炎症反应/核因子κB受体活化因子/核因子κB受体活化因子配体/骨保护素Key words
Bone immunology/Traditional Chinese medicine/Rheumatoid arthritis/Bone destruction/Inflammatory responses/Receptor activator of nuclear factor kappa-B/Receptor activator of nuclear factor kappa-B ligand/Osteoprotegerin引用本文复制引用
基金项目
国家自然科学基金面上项目(82274421)
广东省中医院中医药科学技术研究专项(YN2020QN16)
出版年
2024
国家科技期刊平台
NSTL
万方数据