基于PI3K/AKT信号通路探讨中药治疗激素性股骨头坏死的研究进展
Chinese Medicine in the Treatment of Steroid-induced Femoral Head Necrosis Based on PI3K/AKT Signaling Pathway:A Review
封潇添 1马剑雄 2王岩 2申佳慧 1周丽芸 2李奕扬 2孙亚迪 2董本超 2李岩 2杨培川 2李光 2马天成 2崔洪伟 2王祺钰 1马信龙2
作者信息
- 1. 天津大学天津医院,天津,300211;天津市骨科研究所,天津,300050;天津市骨科生物力学与医学工程重点实验室,天津,300050;天津中医药大学中西医结合学院,天津,301617
- 2. 天津大学天津医院,天津,300211;天津市骨科研究所,天津,300050;天津市骨科生物力学与医学工程重点实验室,天津,300050
- 折叠
摘要
激素性股骨头坏死是非创伤性股骨头坏死中最常见的类型,在非创伤性股骨头坏死中占比高达1/3.但现有疗法无法有效延缓该疾病的进展,髋关节置换术往往是晚期股骨头坏死患者的唯一选择.因此寻找一种防治激素性股骨头坏死的新型保髋疗法,减轻患者的痛苦和经济负担是目前亟须解决的难题.近年来研究发现磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT)信号通路与激素性股骨头坏死的发病联系紧密,靶向PI3K/AKT信号通路用药对激素性股骨头坏死疗效显著.中草药是我国中医学的结晶,使用中药治疗疾病具有多靶点、低成本、低不良反应的特点.随着中药药理学研究的不断深入,众多具有补肾强骨、活血化瘀等功效的中药单体和复方被证实能够通过调控PI3K/AKT信号通路治疗激素性股骨头坏死.
Abstract
Hormone-induced femoral head necrosis is the most common type of non-traumatic femoral head necrosis,accounting for up to 1/3 of such cases.Current treatments are inadequate in effectively delaying the progression of this disease,and hip replace-ment surgery often becomes the only option for advanced cases.Therefore,developing a new hip-preserving treatment to alleviate the suffering and economic burden on patients is an urgent challenge.Recent research has shown a close connection between the phos-phatidylinositol 3-kinase/protein kinase B(PI3K/AKT)signaling pathway and hormone-induced femoral head necrosis.Medications targeting the PI3K/AKT signaling pathway have demonstrated significant efficacy in treating this condition.Chinese herbal medi-cine,a hallmark of traditional Chinese medicine(TCM)science,offers multi-target,low-cost,and low-side-effect therapies.With the ongoing advancement in TCM pharmacology,many Chinese herbal monomers and formulas with functions such as tonifying the kid-neys,strengthening bones,activating blood circulation,and resolving blood stasis have been proven effective in treating hormone-in-duced femoral head necrosis through the regulation of the PI3K/AKT signaling pathway.
关键词
激素性股骨头坏死/中药单体/中药复方/药理研究进展/PI3K/AKT信号通路/内皮细胞/成骨细胞/破骨细胞Key words
Steroid-induced femoral head necrosis/Chinese herbal monomers/Chinese herbal formulas/Advances in pharmaco-logical studies/PI3K/AKT signaling pathway/Endothelial cells/Osteoblasts/Osteoclasts引用本文复制引用
基金项目
国家重点研发计划项目(2022YFC3601904)
天津市自然科学基金重点项目(22JCZDJC00340)
出版年
2024
国家科技期刊平台
NSTL
万方数据