首页|乳没软膏治疗急性闭合性软组织损伤大鼠的抗炎研究

乳没软膏治疗急性闭合性软组织损伤大鼠的抗炎研究

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目的:研究乳没软膏治疗急性闭合性软组织损伤的抗炎镇痛作用.方法:60只斯泼累格·多雷(SD)大鼠(6只备用),分为A组(空白对照组)、B组(模型对照组)、C组(青鹏软膏组)、D组(乳没软膏高剂量组)、E组(乳没软膏中剂量组)、F组(乳没软膏低剂量组);通过建立SD大鼠急性闭合性软组织损伤模型,检测受损组织内肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、前列腺素2(PGE-2)、超氧化物歧化酶(SOD)含量的变化;镜下观察受损组织形态学变化及组织中碱性细胞生长因子(bFGF)含量变化.结果:造模药物干预后,造模组大鼠损伤组织TNF-α、IL-1β、PGE-2含量逐渐下降,其中以C组、D组下降最为明显,B组下降最为缓慢;SOD含量以C组、D组的上升趋势最为明显,B组上升最为缓慢.造模后第2天,各组bFGF蛋白平均光密度值总体比较差异无统计学意义(P＞0.05);造模后第7天、第14天,各组bFGF蛋白平均光密度值总体比较差异有统计学意义(P＜0.05).结论:乳没软膏高剂量组与青鹏软膏在抗炎镇痛方面效果相当.
Anti-inflammatory Effect of Rumo Ointment in the Treatment of Acute Closed Soft Tissue Injury of Rats
Objective:To study the anti-inflammatory and analgesic effects of Rumo ointment in the treatment of acute closed soft tissue injury.Methods:Sixty SD rats(6 spare)were divided into group A(blank control group),group B(model control group),group C(Qingpeng ointment group),group D(high-dose Rumo ointment group),group E(middle-dose Rumo ointment group),and group F(low-dose Rumo ointment group).By establishing the SD rat model of acute closed soft tissue injury,the content of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),prostaglandin E2(PGE2),and superoxide dismutase(SOD)was detected in the damaged tissue.The morphological changes of the damaged tissue and the content changes of basic fibroblast growth factor(bFGF)in the tissue were observed under a microscope.Results:After intervention using modeling drugs,the content of TNF-α,IL-1 β,and PGE-2 in the injured tissues of rats in the modeling groups gradually decreased,among which the decrease in group C and group D was the most obvious,and the decrease in group B was the slowest.The increase in SOD content was the most obvious in group C and group D,and that in group B was the slowest.On the second day after modeling,there was no significant difference in the aver-age optical density of bFGF protein in each group(P＞0.05).On the 7th and 14th days after modeling,the average optical density of bFGF protein in each group was statistically different(P＜0.05).Conclusion:High-dose Rumo ointment and Qingpeng ointment have comparable anti-inflammatory and analgesic effects.

Rumo ointmentQingpeng ointmentAcute closed soft tissue injuryRatTumor necrosis factor-αInterleukin-1 βProstaglandin E2Superoxide dismutase

王永宏、李彦强、梁亚龙、李红专、许伟

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甘肃省中医院静宁分院骨科,平凉,744000

庆阳市中医医院骨科,庆阳,745099

甘肃省中医院骨与软组织肿瘤科,兰州,730050

乳没软膏 青鹏软膏 急性闭合性软组织损伤 大鼠 肿瘤坏死因子α 白细胞介素1β 前列腺素2 超氧化物歧化酶

国家自然科学基金青年科学基金项目甘肃省中医药管理局项目平凉市级重点项目

81704104GZK-2019-19平科任[2021]1号

2024

10.3969/j.issn.1673-7202.2024.16.008

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(16)