Evidence Evaluation,Recommendation,and Rule of Syndrome Differentiation of Ancient TCM Books of Chest Impediment
Objective:To systematically evaluate and recommend formulas for treating chest impediment based on evidence from traditional Chinese medicine(TCM)classics,and to summarize the rule of syndrome differentiation.Methods:The literature was sourced from the 5th edition of the Zhonghua Medical Canon and the National TCM Heritage database developed by the Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences.Ancient formulas for treating chest im-pediment before or up to 1911 were collected and screened.The Grading Scale for Evaluating Evidence of TCM Treatment in Ancient Texts(Chest Impediment)was applied to evaluate and grade the evidence,and a predetermined recommendation standard was used to recommend the evidence.Results:A total of 155 pieces of evidence from TCM classics on the treatment of chest imped-iment were included,with 31 pieces rated as high-level evidence,65 as medium-level evidence,and 59 as low-level evidence.Fol-lowing the"formula-based syndrome differentiation"approach,the identified syndromes for chest impediment were cold coagulation in the heart meridian(34.19%),qi stagnation in the heart meridian(23.87%),blood stasis obstructing the meridian(16.13%),phlegm-turbidity obstruction(9.68%),deficiency of heart yang(5.81%),deficiency of heart qi(4.52%),deficiency of heart yin(3.87%),and obstruction of heart yang(1.94%).Eight pieces of classical evidence were strongly recommended,including Ren-shen Decoction,Fuling Xingren Gancao Decoction,Gualou Xiebai Banxia Decoction,Zhishi Xiebai Guizhi Decoction,and Gualou Xiebai Baijiu Decoction from Synopsis of the Golden Chamber(Jin Gui Yao Lue),Suhexiang Pills and Shixiao Powder from Formu-lary of the Bureau of Taiping People's Welfare Pharmacy(Tai Ping Hui Min He Ji Ju Fang),and Guipi Decoction from Categorized Synopsis of the Whole(Zheng Ti Lei Yao).Four pieces of evidence were weakly recommended,including Wutou Chishizhi Pills,Danshen Decoction,Xuefu Zhuyu Decoction,and Juzhijiang Decoction.Other pieces of evidence were not recommended.Conclu-sion:Synopsis of the Golden Chamber is a classical text with a comprehensive system for syndrome differentiation and treatment of chest impediment.The methods of resolving phlegm and activating blood are fundamental in treating chest impediment,with formu-las like the Gualou Xiebai tri-decoctions and Xuefu Zhuyu Decoction being crucial prescriptions for this condition.
Chest impedimentCoronary artery diseaseAncient books of TCMEvidenceEvidence-based evaluationEvidence recommendationEvaluation scaleRule of syndrome differentiation