世界中医药2024,Vol.19Issue(16) :2448-2454.DOI:10.3969/j.issn.1673-7202.2024.16.012

当归芍药散古今源流及临床应用机制

Origin and Mechanism of Danggui Shaoyao Powder in Clinical Application from Ancient to Modern Times

李鸿 黎柳 黄秋晴 杨诗尧 邹俊驹 向琴 刘秀 肖凡 喻嵘
世界中医药2024,Vol.19Issue(16) :2448-2454.DOI:10.3969/j.issn.1673-7202.2024.16.012

当归芍药散古今源流及临床应用机制

Origin and Mechanism of Danggui Shaoyao Powder in Clinical Application from Ancient to Modern Times

李鸿 1黎柳 1黄秋晴 1杨诗尧 1邹俊驹 1向琴 2刘秀 3肖凡 4喻嵘5
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作者信息

  • 1. 湖南中医药大学中医学院,长沙,410208
  • 2. 湖南中医药大学科技处,长沙,410208
  • 3. 湖南中医药大学方证实验室,长沙,410208
  • 4. 湖南中医药大学国际学院,长沙,410208
  • 5. 湖南中医药大学研究生院,长沙,410208
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摘要

目的:系统梳理有关当归芍药散的古今文献,了解当归芍药散的历史沿革和临床应用概况,为当归芍药散的现代临床应用及研究提供理论基础.方法:在《中华医典》数据库中以"当归芍药散"为关键词搜索有关条目及古代书籍,在国家知识基础设施数据库(CNKI)及PubMed数据库中以"当归芍药散""DangGui ShaoYao San(DSS)"为主题词进行检索,并依据纳入和排除标准筛选,最终总结出当归芍药散的历史沿革与临床研究.结果:古代文献最终纳入111条目,共50部医籍,当归芍药散首载于《金匮要略》,其药物组成、基原、剂量、煎服方法大致延续了仲景书中的记载,书中并未记载当归芍药散的炮制方法、服药反应及禁忌证,但是后世医家及学者对当归芍药散的单个药物进行了考证和探讨,处方配伍比例当为3∶16∶8∶4∶4∶8,方中药物为生品,主治腹痛;现代文献纳入38篇文献,该方具有镇痛抗炎、调节激素水平、降低血脂程度、改善血流状态、提高免疫的功用,主要用于慢性盆腔炎、痛经、黄褐斑、糖尿病肾病等疾病.结论:当归芍药散的组成、基原、剂量、煎煮及服用方法基本上与《金匮要略》保持一致,该方主要适用证型有5型,疾病有10余种.临床治疗上,探究其临床应用机制,扩宽了当归芍药散的应用范围,为经方当归芍药散的开发与应用提供了参考.

Abstract

Objective:To systematically review ancient and modern literature on Danggui Shaoyao Powder(DSP)to understand its historical development and clinical application,providing a theoretical basis for its modern clinical use and research.Methods:The term"Danggui Shaoyao Powder"was used to search relevant entries and ancient texts in the Zhonghua Medical Canon database.Additionally,China National Knowledge Infrastructure(CNKI)and PubMed databases were searched using"Danggui Shaoyao Pow-der"and"Danggui Shaoyao San"as keywords.Articles were selected according to inclusion and exclusion criteria,and the histori-cal evolution and clinical research on DSP were summarized.Results:A total of 111 entries from 50 medical texts were included from ancient literature.DSP was first recorded in the Synopsis of the Golden Chamber(Jin Gui Yao Lue),and its composition,origi-nal sources,dosage,and decoction methods largely followed the descriptions by ZHANG Ji.The original text did not record process-ing methods,adverse reactions,or contraindications for DSP.However,later physicians and scholars examined and discussed the in-dividual drugs in the formula.The composition ratio of the prescription was identified as 3∶16∶8∶4∶4∶8,using raw herbs,and it was primarily indicated for abdominal pain.In modern literature,38 studies were included,highlighting the analgesic,anti-inflammatory,hormone-regulating,lipid-lowering,blood circulation-improving,and immune-boosting effects.DSP has been mainly used to treat chronic pelvic inflammatory disease,dysmenorrhea,chloasma,diabetic nephropathy,and other conditions.Conclusion:The composi-tion,original sources,dosage,and methods of decoction and administration of DSP have remained largely consistent with those de-scribed in the Synopsis of the Golden Chamber.The formula is mainly applicable to five syndromes and over ten diseases.Clinical-ly,exploring its mechanisms of action has broadened the application range of DSS,providing a reference for the development and use of this classical prescription.

关键词

当归芍药散/《金匮要略》/文献研究/临床应用/作用机制/理论源流/组方应用/张机

Key words

Danggui Shaoyao Powder/Synopsis of the Golden Chamber/Literature review/Clinical application/Mechanism/Theoretical origins/Application of formula/ZHANG Ji

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基金项目

国家自然科学基金联合基金重点支持项目(U21A20411)

国家自然科学基金面上项目(82074400)

湖南省研究生科研创新项目(CX20220772)

出版年

2024
世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子:1.266
ISSN:1673-7202
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