世界中医药2024，Vol.19Issue(17) ：2621-2626.DOI:10.3969/j.issn.1673-7202.2024.17.013

蒲地蓝消炎口服液治疗小儿支原体肺炎有效性和安全性的Meta分析

Meta-analysis of Efficacy and Safety of Pudilan Antiphlogistic Oral Liquid in Treating Mycoplasma Pneumonia in Children

王雅星 姜甘 吕健 路振凯 黎元元 谢雁鸣
世界中医药2024，Vol.19Issue(17) ：2621-2626.DOI:10.3969/j.issn.1673-7202.2024.17.013
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  • 维普
  • 万方数据

蒲地蓝消炎口服液治疗小儿支原体肺炎有效性和安全性的Meta分析

Meta-analysis of Efficacy and Safety of Pudilan Antiphlogistic Oral Liquid in Treating Mycoplasma Pneumonia in Children

王雅星 1姜甘 2吕健 3路振凯 1黎元元 1谢雁鸣1
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作者信息

  • 1. 中国中医科学院中医临床基础医学研究所,北京,100700
  • 2. 中国中医科学院中医临床基础医学研究所,北京,100700;中国中医科学院西苑医院,北京,100091
  • 3. 中国中医科学院西苑医院,北京,100091
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摘要

目的:系统评价中成药蒲地蓝消炎口服液联合西药治疗小儿支原体肺炎(MPP)的临床有效性和安全性.方法:通过全面检索关于蒲地蓝消炎口服液联合西药治疗小儿支原体肺炎的随机对照试验(RCT)文献,利用统计软件RevMan5.3提取并分析数据.结果:共纳入13项研究,共包含1 313例患者,其中观察组661例,对照组652例.蒲地蓝消炎口服液联合西药治疗小儿支原体肺炎,临床有效率高于单用西药(RR=1.17,95％CI为1.13～1.22,P＜0.000 1),退热时间(MD=-1.29,95％CI 为-1.35～-1.22,P＜0.000 1),听诊肺部啰音消退时间(MD=-1.77,95％CI 为-1.85～-1.69,P＜0.000 1)及咳嗽症状消退时间(MD=-2.59,95％CI为-2.67～-2.52,P＜0.000 1)4个方面均优于单用西药.GRADE评价结果显示证据质量以低质量为主.结论:蒲地蓝消炎口服液联合西药优于单独应用西药,且不良反应较少,安全性较好.

Abstract

Objective:To systematically evaluate the clinical efficacy and safety of Pudilan Antiphlogistic Oral Liquid combined with Western medicine in the treatment of mycoplasma pneumonia(MPP)in children.Methods:A comprehensive search was con-ducted for randomized controlled trials(RCTs)on the use of Pudilan Antiphlogistic Oral Liquid combined with Western medicine for treating pediatric MPP.Data were extracted and analyzed using the statistical software RevMan 5.3.Results:A total of 13 stud-ies involving 1 313 patients were included,with 661 patients in the observation group and 652 in the control group.The clinical effi-cacy of Pudilan Antiphlogistic Oral Liquid combined with Western medicine was higher than that of Western medicine alone(RR=1.17,95％CI 1.13 to 1.22,P＜0.000 1).The combined treatment also showed better outcomes in terms of fever resolution time(MD=-1.29,95％CI-1.35 to-1.22,P＜0.000 1),lung rale resolution time on auscultation(MD=-1.77,95％CI-1.85 to-1.69,P＜0.000 1),and cough symptom resolution time(MD=-2.59,95％CI-2.67 to-2.52,P＜0.000 1)compared to Western medicine alone.The GRADE evaluation indicated that the quality of evidence was generally low.Conclusion:Pudilan Antiphlogistic Oral Liquid combined with Western medicine is more effective than Western medicine alone in treating pediatric MPP,with fewer adverse reactions and better safety.

关键词

小儿支原体肺炎/蒲地蓝消炎口服液/阿奇霉素/随机对照试验/中西医结合疗法/临床疗效/Meta分析

Key words

Mycoplasma pneumonia in children/PDL Antiphlogistic Oral Liquid/Azithromycin/Randomized controlled trail/Combined therapy of traditional Chinese and Western medicine/Clinical efficacy/Meta-analysis

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出版年

2024
世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
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