Analysis of Animal Models of Traumatic Spinal Cord Injury Based on Data Mining
Objective:To explore the current status of traumatic spinal cord injury(TSCI)animal models.Methods:Relevant ex-perimental journal articles were retrieved from the China National Knowledge Infrastructure(CN KI),China Academic Journal Data-base(CSPD),Chinese Sci-tech Journal Database(CCD),and PubMed databases using the keywords"traumatic spinal cord injury"and"animal model".The articles were categorized and ranked according to factors such as species and sex of experimental ani-mals,model induction methods,model categories,detection indicators,and the use of positive control drugs.The frequency and ap-plication proportions of each factor were statistically analyzed,and a database was established to analyze the characteristics of the models,existing issues,and recommendations.Results:Among the 157 articles included,the most commonly used animal was the male Sprague-Dawley(SD)rat.The most frequently used model induction method was spinal cord impact using a spinal cord im-pactor.The majority of the models were categorized as incomplete spinal cord injury.Methylprednisolone was the most commonly used positive control drug,administered via tail vein injection.The model evaluations primarily focused on motor function,cell mor-phology of spinal cord injury site,and the expression of relevant cytokines and proteins.Conclusion:For TSCI animal models,it is recommended to use male SD rats and induce incomplete spinal cord injury using a spinal cord impactor.Methylprednisolone is the suggested positive control drug,administered via tail vein injection.Model success can be evaluated using motor function tests,cell morphology of spinal cord injury site,and analysis of relevant cytokines and protein expressions.
TSCISpinal cord injuryAnimal modelData miningDetection indexModel evaluationInduction modeRoute of medication
万方数据
维普
