Diagnosis and Treatment of Low-risk Myelodysplastic Syndromes from Liver,Spleen,and Kidney
Myelodysplastic syndromes(MDSs)are a group of hematopoietic stem cell-derived and heterogeneous myeloid clonal disorders.In recent years,the treatment of low-risk MDS primarily involves supportive therapies such as component blood transfu-sions,immunosuppressive agents,immunomodulators,and demethylating agents.Low-risk MDS is categorized within the broader spectrum of myelotoxic diseases,and the disease course is relatively long.It is considered to be in the stage of"positive and nega-tive forces in flux",where the imbalance of yin and yang is still in a phase of gradual development.Patients generally exhibit a con-dition of"healthy qi deficiency",where the pathogenic qi has not yet fully developed.Treatment methods mainly focus on tonifying the body's healthy qi.The pathological mechanisms of low-risk MDS can be summarized as follows.Innate deficiency and acquired damage to the spleen and stomach lead to an inability to generate sufficient qi and blood.Alternatively,toxic substances may dam-age the bone marrow and lead to marrow depletion,resulting in deficiency of essence and blood,and a lack of source for the genera-tion of new blood.Chronic illness can lead to liver qi stagnation,where liver qi becomes constrained,causing qi stagnation and blood stasis,preventing the clearing of stagnated blood and inhibiting the generation of new blood.The pathogenesis is related to five or-gans,but closely to the liver,spleen,and kidney,and treatment should primarily focus on invigorating the spleen,tonifying the kid-neys,and soothing the liver.
Weakness of the spleen qiDeficiency of kidney-essenceLiver depression and qi stagnationBanking up earth to benefit middle energizerNourishing water to consolidate lower energizerNourishing wood to clear upper energizerrisk stratifica-tionmyelodyspla
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