Clinical Characteristics of Inpatients with Sj?gren's Syndrome-interstitial Lung Disease
Objective:To explore the clinical differences between inpatients with Sjögren's syndrome and interstitial lung disease(SS-ILD)and those without interstitial lung disease(SS-NILD),providing objective theoretical support for the early diagnosis and subsequent clinical treatment of SS-ILD.Methods:Clinical data from inpatients with SS-ILD and SS-NILD meeting the inclusion criteria were collected.Statistical analysis was conducted on basic information,clinical manifestations,syndrome types based on tongue and pulse diagnosis,laboratory tests,and treatment regimens.Results:A total of 299 patients were included,with 87 in the SS-ILD group and 212 in the SS-NILD group.The SS-ILD group had a higher probability of being older,having a history of smoking and alcohol use,experiencing respiratory symptoms,having no or desquamated tongue coating,and having weak pulses.This group also had lower oxygen partial pressure,higher erythrocyte sedimentation rate,C-reactive protein levels,and rheumatoid factor posi-tivity rates.Patients diagnosed with the syndromes of yin deficiency with fluid depletion,qi and yin deficiency,and dryness in com-bination with stasis had a higher likelihood of ILD(P<0.05).Regression analysis indicated that ILD was positively correlated with smoking history,cough as the primary complaint,no or desquamated tongue coating,weak pulse,and qi-yin deficiency syndrome,and negatively correlated with dry eye as the primary complaint.Pulmonary function tests in the SS-ILD group mainly showed mild obstructive/restrictive ventilatory dysfunction and mild diffusion dysfunction.High-resolution chest CT in SS-ILD patients primarily showed pleural thickening,nodular shadows,and ground-glass opacities.The main Chinese patent medicines used in the SS-ILD group were formulas containing Cordyceps,while the SS-NILD group predominantly used Tripterygium wilfordii-based preparations.Western medicine treatments were mainly immunosuppressants,or a combination of intermediate-acting glucocorticoids.Conclu-sion:Hospitalized SS patients are primarily elderly women with a smoking history and respiratory symptoms.Traditional Chinese medicine diagnosis of qi-yin deficiency is associated with the presence of ILD.Clinical treatment focuses on anti-inflammatory and immune-regulatory therapies,with further promotion of biologics still needed.
Sjögren's syndromeInterstitial lung diseaseInpatientsClinical characteristicsTreatment planTraditional Chinese medicine tongue and pulseTraditional Chinese medicine syndrome typesRetrospective research