Characteristics of Pulse Diagnosis Information of Coronary Heart Disease with Phlegm and Blood Stasis Syndrome
Objective:To analyze the pulse diagnosis information characteristics of coronary heart disease(CHD)with the syn-drome of phlegm and blood stasis,and provide an objective basis for identifying CHD syndromes.Methods:Pulse diagnosis data from CHD patients with phlegm and blood stasis syndrome and without this syndrome(control group)were collected and analyzed.Unsupervised principal component analysis(PC A)and supervised learning methods including Least Squares(LS)regression and Lasso regression were used for classification and decision-making.Results;The right-hand Cun pulse time-domain parameters in the 1st and 9th principal components,along with the frequency-domain phase parameters of both hands,showed statistically significant differences in t-tests and F-tests.The supervised LS model achieved an overall classification accuracy of 74%in distinguishing be-tween the phlegm and blood stasis syndrome group and the control group.In distinguishing the phlegm and blood stasis syndrome group from other syndromes,including phlegm obstruction and heat accumulation,qi stagnation and blood stasis,qi deficiency and blood stasis,qi and yin deficiency,and yang deficiency and cold congealing,the LS model achieved accuracy rates of 69%to 78%.In Lasso regression analysis,the classification accuracy between the phlegm and blood stasis syndrome group and the control group was 74%.The main parameters distinguishing the two syndromes were concentrated in frequency-domain phase parameters,inclu-ding left Cun phase 3,left Cun phase 6,left Guan phase 6,right Guan phase 6,and right Chi phase 12.The most significant parame-ter distinguishing the phlegm and blood stasis syndrome group from the control group was the right Cun S2 time-domain feature.Conclusion:After corresponding analysis of pulse diagnosis data and traditional Chinese medicine(TCM)theory,the main differ-ences in pulse information between phlegm and blood stasis syndrome and non-phlegm and blood stasis syndrome were found in the frequency-domain parameters of both the Cun and Chi pulses.Particularly,the right Cun S2 time-domain difference was significant in identifying the characteristics of phlegm and blood stasis in CHD with phlegm turbidity and blood stasis syndrome.This reflects the important role of the"lung governing management and regulation"in the distribution of qi,blood,and essence.
Pulse characteristicsPrincipal component analysisRegression analysisTime-domain differenceSupervised learn-ingCoronary heart diseasePhlegm and blood stasis syndromePhlegm turbidityLung governing management and regulation