内质网应激在多囊卵巢综合征中的作用及中医药治疗研究进展

Effect of Endoplasmic Reticulum Stress in PCOS and the Treatment with Traditional Chinese Medicine:A Review

李婧 ¹孙畅 ¹徐珂 ¹赵珊珊 ¹匡洪影 ²王颖 ²孙淼 ²王海强 ²顾雯方¹

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作者信息

1. 黑龙江中医药大学,哈尔滨,150040
2. 黑龙江中医药大学附属第一医院,哈尔滨,150040
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摘要

多囊卵巢综合征(PCOS)是一种复杂的多因素内分泌代谢紊乱,其确切病因不明.越来越多研究指出内质网应激(ERS)因颗粒细胞功能障碍、雄激素过多、胰岛素抵抗、肥胖以及氧化应激等进一步加重PCOS患者体内代谢紊乱,从而促进PCOS病理发展.中医药治疗应用中药单体、复方及针灸等,可有效改善PCOS患者ERS状态,从而缓解临床症状提高生命质量.

Abstract

Polycystic ovary syndrome(PCOS)is a complex,multifactorial endocrine-metabolic disorder with an unclear etiology.Increasing research indicates that endoplasmic reticulum stress(ERS),caused by granulosa cell dysfunction,excess androgens,in-sulin resistance,obesity,and oxidative stress,further exacerbates metabolic dysregulation in PCOS patients,thus promoting the path-ological development of the condition.Traditional Chinese medicine(TCM)treatments,including herbal monomers,compound pre-scriptions,and acupuncture and moxibustion,can effectively improve the ERS status in PCOS patients,thereby alleviating clinical symptoms and improving quality of life.

关键词

多囊卵巢综合征/内质网应激/未折叠蛋白反应/中医药治疗/颗粒细胞/胰岛素抵抗/肥胖/氧化应激

Key words

Polycystic ovary syndrome/Endoplasmic reticulum stress/Unfolded protein response/Traditional Chinese medicine treatment/Granulosa cells/Insulin resistance/Obesity/Oxidative stress

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出版年

2024

世界中医药

世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心

影响因子：1.266

ISSN：1673-7202

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