世界中医药2024,Vol.19Issue(20) :3219-3226.DOI:10.3969/j.issn.1673-7202.2024.20.026

中医药调控炎症反应干预肝性脑病的研究进展

Research Progress on TCM in Intervention of Hepatic Encephalopathy by Regulating Inflammatory Reaction

陈玮钰 王涵 付蕾 张广发 蔡颖莹 赖小群 姚春
世界中医药2024,Vol.19Issue(20) :3219-3226.DOI:10.3969/j.issn.1673-7202.2024.20.026

中医药调控炎症反应干预肝性脑病的研究进展

Research Progress on TCM in Intervention of Hepatic Encephalopathy by Regulating Inflammatory Reaction

陈玮钰 1王涵 1付蕾 2张广发 2蔡颖莹 1赖小群 1姚春2
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作者信息

  • 1. 广西中医药大学研究生院,南宁,530001
  • 2. 广西中医药大学,南宁,530001
  • 折叠

摘要

肝性脑病(HE)是威胁肝病患者生命质量和增加社会医疗负担的全球重大健康难题.迄今HE的发病机制仍未阐明,临床治疗仍深陷困境,现有研究表明炎症反应与HE的发生发展密切相关.中医对HE的理论研究日益深入,中医药干预HE显示出巨大的临床应用潜力,具有多靶点、多途径、多环节的疗效优势.现就炎症反应与HE的关系、中医学关于HE的认识以及中医药干预HE相关炎症信号通路3个方面的研究现状进行归纳总结,以期为后续HE的防治研究提供参考和依据.

Abstract

Hepatic encephalopathy(HE)poses a significant global health challenge,threatening the quality of life for liver disease patients and increasing the burden on healthcare systems.The mechanisms underlying HE remain unclear,and clinical treatment continues to face difficulties.Current research indicates a close relationship between inflammatory responses and the development of HE.Traditional Chinese medicine(TCM)has deepened its theoretical understanding of HE,showing substantial clinical application potential in intervening in this condition.TCM demonstrates advantages through multi-target,multi-pathway,and multi-link efficacy.This study reviewed the relationship between inflammatory responses and HE,TCM understanding of HE,and TCM interventions on inflammatory signaling pathways related to HE,aiming to provide a reference and basis for future research on the prevention and treatment of HE.

关键词

肝性脑病/神经炎症/外周炎症/中医药/信号通路/血脑屏障/肠道屏障/研究进展

Key words

Hepatic encephalopathy/Neuroinflammation/Peripheral inflammation/Traditional Chinese medicine/Signaling path-way/Blood-brain barrier/Intestinal barrier/Research progress

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出版年

2024
世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子:1.266
ISSN:1673-7202
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