As a new type of percutaneous drug delivery medical product with high efficiency,safety,simple molding,energy conservation and environmental protection,polymer microneedle had gradually been focused by people.To explore the efficiency of polymer microneedles in vitro delivery of traditional Chinese medicine.Poly lactic acid(PLA)microneedles were prepared by microinjection under the known process conditions.The morphology of PLA microneedles was observed by scanning electron microscopy,and the micro channels were observed by paraffinic section after puncture of mouse abdominal skin.At the same time,the delivery efficiency of Chinese medicine solution pretreated by PLA microneedles was evaluated by in vitro transdermal diffusion.The results showed that the PLA microneedle with a needle height was 520 μm had sufficient mechanical properties to penetrate the cuticle of rat skin.In the microneedle pretreatment and untreated Franz diffusion experiments,the light absorption value of the Gubitongfang was 1.086 881 and the latter was 0.090 04 after 120 min.After linear fitting,the drug concentration of the microneedle pretreatment experimental group was at least 10 times that of the untreated control group.
维普
万方数据