Hydrogel-Forming microneedle is made from the hydrogel material with three-dimenonal network structure.Microneedle body can pierce the stratum corneum of the skin,absorb the interstitial fluid of the skin,swell and transform into a gel state.This property makes it play an important role in the transdermal penetration of drugs and the extraction and identification of biomarkers in the skin.Hydrogel-Forming microneedle can increase the transdermal permeability of the drug and is convenience.Because the tip of the needle is only micron length,it can achieve the purpose of painless/slight pain.There is no matrix residue in the skin after use,and the drug release rate can be adjusted by changing the crosslinking degree of hydrogel.Therefore,the representative literature of hydrogel-Forming microneedle at home and abroad in recent years are summarized,the latest research progress in preparation technology,performance evaluation methods and applications are introduced.
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