Curcumin/chitosan drug film was prepared using a solution casting method with glacial acetic acid as the solvent,glutaraldehyde as the crosslinking agent,chitosan as the carrier,and curcumin as the drug model.The components and thermal stability of the composite material were investigated by infrared spectroscopy and thermogravimetry.In addition,the water absorption,drug loading and sustained release properties of the drug film were evaluated.It was found that at a glutaraldehyde concentration of 0,the equilibrium swelling degree of the drug film was(406.67±0.51)％,while at a glutaraldehyde concentration of 4％(volume ratio),the equilibrium swelling degree decreased to(186±2.46)％.Within the experimental formulation range,the optimal glutaraldehyde concentration was 3％,chitosan concentration was 2％,and curcumin loading was 2％.The release rate at 20 hours was 66.91％,indicating that the prepared drug film had a certain sustained-release ability.It was found that the drug release mechanism basically conformed to the first-order equation model,and the fitting equation was Mt=73.561 67(1-e-0 138 46').
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