Research Progress on the Role of Gut Microbiota in the Pathological Mechanisms of Alzheimer's Dis-ease
Alzheimer's disease(AD)is a progressive neurodegenerative disease,the pathogenesis of which remains unclear.Recent studies have shown that the gut microbiota can affect the host's cognition and behavior by affecting central nervous system function,making it a potential thera-peutic target for neurodegenerative diseases.Dysbiosis of the gut microbiota and disruption of the intestinal physiological barrier can induce peripheral inflammatory responses,which,through mediating the release of physiologically active substances such as neurotransmitters and microbio-ta secretions,can affect neurogenesis and neuronal signaling,resulting in inflammatory reactions in the central nervous system,synergistically promoting the neurodegenerative progression of AD pathology.Therefore,investigations into the possible mechanisms by which dysbiosis of the gut microbiota affects the pathology of AD may provide new perspectives for the prevention and alle-viation of AD,offering new strategies for promoting healthy aging.
gut microbiotaAlzheimer's diseaseinflammationneuroinflammationneurotransmit-ter
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