Chemotherapy-Associated Vascular Endothelial Injury and Protection
With the rapid development of tumor chemotherapy,the overall survival of tumor pa-tients has been continuously prolonged.However,the cardiovascular toxic side effects caused by chemotherapy seriously limit the effectiveness of tumor treatment,and have become a high-risk factor affecting the quality of life and survival rate of patients.Among them,chemotherapy-re-lated vascular endothelial injury can disrupt vascular homeostasis,which serves as the pathologi-cal basis of cardiovascular toxic side effects such as acute vascular events(vasospasm,acute myo-cardial infarction,stroke,etc.),atherosclerosis,hypertension,and aneurysms.Exploring the mechanisms and protective strategies of chemotherapy-related vascular endothelial injury is of great clinical significance.This review aims to summarize the latest progress in the mechanisms of chemotherapy-associated vascular endothelial injury and related protective strategies.
万方数据
维普
