Controlled ovarian hyperstimulation(COH)is an essential part of assisted reproduc-tive technology,which significantly improves the pregnancy rates of in vitro fertilization-embryo transfer(IVF-ET).Despite the clear benefits of COH in promoting follicular development,in-creasing oocyte count,and enabling the selection of high-quality embryos for transfer,COH may involve changes in the implantation window,endometrial receptivity,progesterone and estradiol levels,as well as uterine contractility,potentially impacting embryo implantation and IVF preg-nancy rates in infertile patients.This article reviews the pathophysiological mechanisms of endo-metrial changes resulting from COH,with the aim of better addressing the bottleneck problems in the clinical treatment of infertility.
关键词
控制性超促排卵/子宫内膜/体外受精/胚胎移植
Key words
controlled ovarian hyperstimulation/endometrium/in vitro fertilization/embryo transfer