炎症性肠病(inflammatory bowel disease,IBD)是以克罗恩病(Crohn's disease,CD)和溃疡性结肠炎(ulcerative colitis,UC)为代表的慢性肠道炎症性疾病,机制涉及遗传易感性以及环境与微生物群间相互作用削弱肠道屏障导致免疫激活等多种途径.近年来,巨噬细胞上表达的TREMs(triggering receptors expressed on myeloid cells),即髓系细胞触发受体,被发现在固有免疫和适应性免疫中发挥重要作用,并与IBD的发生发展密切相关.本文将着重对TREM-1/2(TREM-1和TREM-2)的结构、配体和作用,其在巨噬细胞上参与IBD与伴发精神障碍的机制研究进行概述,旨在为IBD的预防和治疗提供理论支持.
Abstract
Inflammatory bowel disease(IBD)is a chronic intestinal inflammatory disease repre-sented by Crohn's disease(CD)and ulcerative colitis(UC).Mechanisms underlying its onset and development involve genetic susceptibility,as well as multiple pathways such as the environmen-tal and microbial interactions that weaken the intestinal barrier and lead to immune activation.Recent research has indicated that triggering receptors expressed on myeloid cells(TREMs)ex-pressed on macrophages play critical roles in both innate and adaptive immune responses,closely associated with the occurrence and development of IBD.This article reviews the structures,lig-ands,and functions of TREM-1/2(TREM-1 and TREM-2),as well as mechanisms underlying the involvement of TREM-1/2 in IBD and the accompanying mental disorders,aiming to provide theoretical support for the prevention and treatment of IBD.
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