Roles and Mechanisms of Complement C1q TNF-Related Protein 7 in Cardiometabolic Disease
李定微 1钱帅伟 2李春艳2
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作者信息
1. 武汉体育学院运动医学院,武汉 430070
2. 武汉体育学院运动医学院,武汉 430070;运动训练监控湖北省重点实验室,武汉 430070
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摘要
心血管代谢性疾病(cardiometabolic disease,CMD)是指代谢系统和心血管系统单一或者同时发生、可相互影响的病理改变,是代谢性疾病和心血管疾病的总称.包括肥胖、胰岛素抵抗、代谢综合征、糖尿病以及冠心病等.脂肪因子在CMD的发生发展中发挥关键性作用.补体C1q肿瘤坏死因子相关蛋白7(complement C1q TNF-related protein 7,CTRP7)是新近发现的脂肪因子,与肥胖、糖尿病及冠心病等CMD密切相关.本文围绕CTRP7生物学特性,综述其在CMD(包括肥胖、2型糖尿病和冠心病)发生发展中的作用,及可能的作用机制如多种途径调控糖脂代谢、降低胰岛素敏感性、促进炎症反应和增加氧化应激等,以期为CTRP7作为CMD的治疗靶标提供依据和参考.
Abstract
Cardiometabolic disease(CMD)refers to the single or simultaneous occurrence of pathological changes in the metabolic and cardiovascular systems that can mutually influence each other,which is a collective term for metabolic and cardiovascular diseases,including obesity,insu-lin resistance,metabolic syndrome,diabetes,and coronary heart disease,etc.Adipokines play a critical role in the occurrence and development of CMD.Complement C1q TNF-related protein 7(CTRP7)is a recently discovered adipokine closely associated with CMD,such as obesity,diabe-tes and coronary heart disease.Focusing on the biological characteristics of CTRP7,this article reviews its role in the occurrence and development of CMD,including obesity,type 2 diabetes mellitus and coronary heart disease,as well as the possible mechanisms such as regulating glu-cose and lipid metabolism,decreasing insulin sensitivity,promoting inflammatory responses and increasing oxidative stress,so as to provide evidence and references for CTRP7 as a therapeutic target of CMD.
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