Physiological Roles of the Mechanosensitive Channel Piezo1
Mechanotransduction occurs when tissues or cells are stimulated by external mechani-cal forces,initiating a series of signaling processes,with mechanosensitive ion channels playing a pivotal role in this signaling cascade.Among these channels,Piezo1 has been widely studied.Pi-ezo1 has been found in a variety of mammalian tissues and can affect multiple signaling pathways after mechanical stimulation,involving processes such as vasodilation,cell migration,and in-flammatory response.To explore the potential therapeutic value of Piezo1 and improve the un-derstanding of its function,this article reviews literature on Piezo1 and summarizes the latest re-search progress on Piezo1 in the cardiovascular system,locomotor system,nervous system,re-spiratory system,digestive system,and reproductive system.