Research Progress on the Role and Mechanisms of Hypoxia in the Progression of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease(NAFLD)is a prevalent chronic non-infectious liver disease nationwide that can progress to liver cirrhosis and liver cancer,posing a significant threat to human health.Under hypoxic conditions at high altitudes,various organs and systems of the body are affected.Liver tissues,in particular,experience intensified hypoxia,leading to a signifi-cantly higher prevalence of NAFLD in plateau areas than in sea level areas.Currently,there are diverse opinions on the pathogenesis of NAFLD,and the specific mechanisms by which high-alti-tude hypoxia promotes NAFLD progression remain unclear.In this article,we review the impact of high-altitude hypoxia on liver parenchymal cells and mesenchymal cells,consolidate relevant research findings,and summarize the potential mechanisms by which high-altitude hypoxia may contribute to the progression of chronic NAFLD,providing new insights for the prevention and treatment of NAFLD.
NAFLDhypoxiasteatosisinflammationfibrosis development
万方数据
维普
