N6-methyladenosine(m6A),which belongs to the field of the epigenetic modifications,is a common and reversible mRNA modification in eukaryotic RNA.Regulated by methyltrans-ferases,demethyltransferases,and reader proteins,m6A modification affects the expression of relevant proteins by mediating RNA transcription,splicing,translation,and other processes,thereby regulating the physiological and biochemical processes of the organism.Major depressive disorder(MDD),characterized by a high incidence,low cure rate,and a high recurrence rate,is a psychiatric disorder with multiple etiological factors,including genetic factors,environmental factors and epigenetic factors.However,the specific mechanisms underlying MDD remain un-clear.Recent studies have found a close relationship between m6A modification and the pathogen-esis of MDD,making it a hot topic in MDD research.This article reviews the m6A methylation,as well as the expression and roles of related enzymes in the central nervous system of MDD pa-tients,aiming to provide new insights and potential drug targets for the research and treatment of MDD.
关键词
N6-甲基腺苷/重度抑郁症/甲基化/m6A甲基转移酶/m6A去甲基化酶
Key words
N6-methyladenosine(m6A)/major depressive disorder/methylation/m6A methyl-transferase/m6 A demethyltransferase
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