Chronic pain and depression are two common diseases that endanger human health.They often co-occur and mutually influence each other,greatly increasing the difficulty of treat-ment.The occurrence of chronic pain and depression involves common or interacting neural cir-cuits and neurotransmitter systems.Neuroinflammation also plays an important role in the path-ogenesis of chronic pain and depression.Dysfunction in related neural circuitry and neuroinflam-mation are important mechanisms underlying the comorbidity between chronic pain and depres-sion.Chronic stress is a critical cause of inducing depression and chronic pain.Previous studies have shown that dysfunction of the hypothalamic-pituitary-adrenal(HPA)axis is the pathological basis for chronic stress-induced depression and comorbid pain.Chronic stress may promote neu-roinflammatory response and dysfunction of neural circuits through HPA axis dysfunction,lead-ing to the comorbidity of chronic pain and depression.This review discusses the pathogenesis of chronic stress-induced pain comorbid with depression,and elaborates on the pathogenesis of chro-nic stress-induced comorbidity of chronic pain and depression from the aspects of the HPA axis function,neuroinflammation,brain structure and neural circuits involved.
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