Ischemic stroke is a leading cause of death and disability worldwide,with a complex pathogenesis and limited therapeutic options.In recent years,nano-drug delivery systems(NDDS)have shown great potential in the treatment of brain diseases.Nanocarriers can trans-port drugs across the blood-brain barrier and target diseased cells through the modification of tar-geting ligands.This article reviews the pathogenesis of ischemic stroke and the limitations of cur-rent therapeutic approaches,focusing on the progress of nano-drug delivery systems in the treat-ment of ischemic stroke.The challenges and future directions in this field are proposed,aiming to advance the development of nanomedicine delivery systems for the treatment of ischemic stroke.
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