烟酰胺-N-甲基转移酶在癌症发生发展中的作用研究进展
Advances in the Role of Nicotinamide-N-Methyltransferase in Cancer Initiation and Progression
张宁宁 1马玲君 2康静依 1娄烁 1梁元晶 1翁静 1马伟1
作者信息
- 1. 首都医科大学基础医学院组织学与胚胎学教研室,北京 100069
- 2. 宁夏吴忠市利通区人民医院麻醉科,吴忠 751100
- 折叠
摘要
烟酰胺-N-甲基转移酶(nicotinamide N-methyltransferase,NNMT)利用S-腺苷甲硫氨酸作为甲基供体,将烟酰胺转变为1-甲基烟酰胺.NNMT在肝脏组织、脂肪组织和某些癌组织中高表达,并在神经退行性疾病、肥胖和糖尿病患者的特定细胞中也呈现表达增加的趋势,因而国内外对NNMT的关注度上升.本文概述了 NNMT在癌细胞迁移和侵袭、耐药性、凋亡、自噬等方面的作用,并对相关上下游的分子通路进行综述.
Abstract
Nicotinamide N-methyltransferase(NNMT)converts nicotinamide(NAM)to 1-meth-ylnicotinamide(1-MNA)using S-adenosylmethionine(SAM)as a methyl donor.NNMT has re-cently attracted increasing attention as it is highly expressed in liver tissues,adipose tissues and certain cancer tissues,and also exhibits increased expression in specific cells of patients with neu-rodegenerative diseases,obesity and diabetes.This article provides an overview of the role and associated upstream and downstream molecular pathways of NNMT in cancer cell migration and invasion,drug resistance,apoptosis,and autophagy,in an attempt to facilitate better under-standing of the function and molecular mechanisms of NNMT in cancer initiation and progres-sion.
关键词
烟酰胺N-甲基转移酶/S-腺苷甲硫氨酸/转移/耐药性/分子通路/癌症Key words
NNMT/SAM/metastasis/chemosensitivity/molecular pathways/cancer引用本文复制引用
出版年
2024
NETL
NSTL
万方数据