IL-15的免疫调节功能及其相关疾病研究进展
Research Progress on the Immunomodulatory Function and Associated Diseases of IL-15
聂亚丹 1贺毅 1孙作厘 1杨健 1罗燕婷 1刘明霞 1王海霞1
作者信息
- 1. 首都医科大学附属北京安定医院,国家精神疾病医学中心,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京 100088;首都医科大学人脑保护高精尖创新中心,北京 100069
- 折叠
摘要
IL-15作为免疫调控的关键分子,主要由髓系细胞分泌产生.IL-15在T细胞、自然杀伤细胞和记忆CD8+T细胞稳态和功能方面发挥重要作用,因其具有广泛表达、严格分泌的特性在多种免疫相关疾病中体现出良好的治疗潜能.IL-15与IL-15受体特异性结合后,激活下游JAK/STAT、Ras/Raf/MAPK及PI3K/AKT等多种信号通路,通过诱导细胞增殖、分化和凋亡,从而发挥抗肿瘤、抗感染等生物学效应.本文主要综述了 IL-15在肿瘤、自身免疫疾病和神经精神疾病等中的作用与相关机制,并总结了以IL-15为潜在治疗靶点的小分子激动剂和抑制剂,以期为深入探究IL-15在免疫系统疾病中的发病机制和药物研究提供科学依据.
Abstract
IL-15 is a key molecule in immune regulation and is secreted by myeloid cells.IL-15 plays an important role in the homeostasis and function of T cells,natural killer(NK)cells,and memory CD8+T cells.Due to its characteristics of wide expression and strict secretion,IL-15 holds significant therapeutic potential in various immune-related diseases.After IL-15 specifically binds to IL-15 receptor,it activates a variety of signaling pathways such as JAK/STAT,Ras/Raf/MAPK and PI3K/AKT,inducing cell proliferation,differentiation and apoptosis,thus exer-ting biological effects such as anti-tumor and anti-infection effects.This article reviews the role and associated mechanisms of IL-15 in diseases such as tumors,autoimmune diseases,cardiovas-cular diseases,and neuropsychiatric diseases,and summarizes the small molecule agonists and antagonists with IL-15 as potential therapeutic targets,aiming to provide a scientific basis for fur-ther investigation of the pathogenesis and drug research of IL-15 in immune system diseases and neuropsychiatric diseases.
关键词
IL-15/IL-15受体/肿瘤/自身免疫疾病/神经精神疾病/激动剂/抑制剂Key words
IL-15/IL-15 receptor/tumor/autoimmune disease/neuropsychiatric disease/ago-nists/antagonists引用本文复制引用
基金项目
国家自然科学基金(31970918)
北京安定医院科研基金(3-2-2022-pt19)
出版年
2024
NETL
NSTL
万方数据