嵌合抗原受体T细胞的肿瘤杀伤作用
Tumor-Killing Effects of Chimeric Antigen Receptor T Cells
黄凯锋 1王月丹 2李海潮1
作者信息
- 1. 北京大学第一医院呼吸与危重症医学科,北京 100034
- 2. 北京大学基础医学院免疫学系,北京 100191
- 折叠
摘要
近年来,嵌合抗原受体T(chimeric antigen receptor T,CAR-T)细胞免疫疗法在血液恶性肿瘤的治疗中取得了重要进展,但在实体瘤方面的应用并不理想.本文对CAR-T细胞的结构、杀伤功能进行了介绍,包括非经典免疫突触的形成、分泌细胞因子、分泌穿孔素和颗粒酶、Fas-FasL(factor associated suicide-Fas ligand)途径以及组成CAR结构成分的改变等杀伤肿瘤的主要机制,比较三种CAR细胞的特点,结合CAR-T细胞治疗实体瘤的挑战,对CAR-T细胞在肿瘤免疫治疗领域未来的研究方向进行了分析.
Abstract
In recent years,significant progress has been made in the field of chimeric antigen re-ceptor T(CAR-T)cell immunotherapy for the treatment of hematologic malignancies,while its application in solid tumors has proven to be less than optimal.This article provides an introduc-tion to the structure and function of CAR-T cells,encompassing key mechanisms underlying tumor cytotoxicity such as the formation of non-classical immune synapses,cytokine secretion,perforin and granzyme release,the Fas(factor-associated suicide)-FasL(Fas ligand)pathway,and alterations in the components constituting the CAR structure.The features of three CAR cell types are compared,and in light of the challenges associated with CAR-T cell therapy for solid tumors,the article analyzes future research directions for CAR-T cells in the field of cancer im-munotherapy.
关键词
嵌合抗原受体T细胞/肿瘤/免疫治疗/杀伤功能/研究进展Key words
chimeric antigen receptor T-cell/tumor/immunotherapy/cytotoxic function/re-search progress引用本文复制引用
基金项目
科技部国家重点研发计划"战略性科技创新合作"重点专项(SQ2021YFE020462)
出版年
2024
NETL
NSTL
万方数据