Tumor-Killing Effects of Chimeric Antigen Receptor T Cells
In recent years,significant progress has been made in the field of chimeric antigen re-ceptor T(CAR-T)cell immunotherapy for the treatment of hematologic malignancies,while its application in solid tumors has proven to be less than optimal.This article provides an introduc-tion to the structure and function of CAR-T cells,encompassing key mechanisms underlying tumor cytotoxicity such as the formation of non-classical immune synapses,cytokine secretion,perforin and granzyme release,the Fas(factor-associated suicide)-FasL(Fas ligand)pathway,and alterations in the components constituting the CAR structure.The features of three CAR cell types are compared,and in light of the challenges associated with CAR-T cell therapy for solid tumors,the article analyzes future research directions for CAR-T cells in the field of cancer im-munotherapy.
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