Research Progress on the Role of the Ubiquitin-Proteasome System in Allergic Rhinitis
Secondary damages in allergic rhinitis,such as inflammation,oxidative stress,and mi-tochondrial dysfunction,are considered key factors in the progression of the disease.Despite the availability of diverse treatment options for allergic rhinitis,including pharmacologic and surgical interventions,the outcomes remain suboptimal,accompanied by multiple side effects.There-fore,there is a critical need to develop novel and effective strategies to improve patient prognosis.The ubiquitin-proteasome system(UPS)is a hub for the processing and metabolism of various functional regulatory proteins in cells,playing a crucial role in maintaining cellular homeostasis.Recent advances in UPS research have unveiled its significant role in various physiological and pathological processes in the human body.It is anticipated that the UPS contributes to the occur-rence and development of allergic rhinitis through multiple targets and pathways.This article ex-plores the role of the UPS in allergic rhinitis focusing on associated signaling pathways,aiming to provide a theoretical basis for further research on the UPS and the treatment of allergic rhinitis.
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