Roles of RNA Modifications in Neurological and Psychiatric Disorders
To date,over 170 types of RNA modifications have been identified.As reversible and dynamic processes,RNA modifications participate in post-transcriptional regulation of mRNA,as well as chromatin and transcriptional regulation.N6-methyladenosine(m6A)modification,the most prevalent one,is currently the most extensively studied and understood type of RNA modification,with an increasing body of research revealing its relevance to the occurrence,devel-opment,and treatment of various diseases.The roles of other RNA modifications are also being progressively elucidated.Previous studies and discussions on RNA modifications in diseases have mainly focused on cancer;however,recent studies have confirmed the participation of RNA mod-ifications in the regulation of neurological and psychiatric disorders.This review aims to summa-rize the roles and mechanisms of RNA modifications in neurological and psychiatric disorders,providing new insights for drug development and clinical treatment.
RNA modificationepitranscriptomicsneurological disorderspsychiatric disordersnervous system
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