The Role of PRMT5 in Neurodevelopment and Neurological Disorders
Epigenetic regulation plays critical roles in the development and homeostasis of the nervous system.Protein arginine methylation is a post-translational modification commonly found in nearly all eukaryotic cells,which regulates a variety of physiological events,such as gene transcription regulation or RNA splicing,via mediating the methylation of histone or non-histone targets.This review aims to recapitulate the regulatory mechanism underlying protein ar-ginine methyltransferase 5(PRMT5)function,and summarize the crucial roles of PRMT5 in neural development and neurological diseases,highlighting its epigenetic regulatory mechanism in the nervous system.
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