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缺氧性细胞损伤的机制研究进展

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缺氧性细胞损伤(hypoxic cell damage)参与多种疾病的发生,严重危害人类的健康,因而对缺氧性细胞损伤机制的深入探索具有重要意义.目前的研究表明缺氧性细胞损伤的发生机制主要与细胞凋亡、自噬、焦亡、铁死亡、铜死亡及parthanatos密切相关.本文主要总结缺氧性细胞损伤的发生机制,阐明其关键因子及其调控机制,以期为涉及缺氧性细胞损伤的相关疾病的防治提供新思路.
Research Progress on the Mechanisms of Hypoxic Cell Damage
Hypoxic cell damage is implicated in the etiology of various diseases,posing a signifi-cant threat to human health.Therefore,a comprehensive exploration of the underlying mecha-nisms of hypoxic cell damage is of crucial importance.Recent research has elucidated a compel-ling correlation between hypoxic cell damage and key cellular processes,including apoptosis,au-tophagy,pyroptosis,ferroptosis,cuproptosis,and parthanatos.The aim of this article is to in-tegrate current knowledge on the mechanisms underlying hypoxic cell injury.It seeks to clarify the critical determinants and regulatory pathways involved in these processes,and to offer inno-vative perspectives on preventive and therapeutic approaches for hypoxia-induced diseases.

apoptosisautophagypyroptosisferroptosishypoxiacuproptosisparthanatos

陈辛玲、翟少倩、吴芷静、曹成珠、吴穹、马雪曼、苏占海

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青海大学研究生院,西宁 810001

青海大学附属医院,西宁 810016

青海大学医学院基础医学部,西宁 810001

青海大学医学院中医系,西宁 810001

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细胞凋亡 自噬 焦亡 铁死亡 缺氧 铜死亡 parthanatos

国家自然科学基金青海省自然科学基金面上项目

323602422023-ZJ-932M

2024

生理科学进展
中国生理学会,北京大学

生理科学进展

CSTPCD北大核心
影响因子:0.635
ISSN:0559-7765
年,卷(期):2024.55(5)