Research Progress on the Modulatory Role of the Endocannabinoid System on Sebaceous Gland Func-tions
The main function of sebaceous glands(SG)is producing sebum,which is an integral component of the skin barrier,regulates the growth of cutaneous microbiota via its acid and anti-microbial lipid content,and modulates skin inflammation and immunity.Dysfunctions of SG play critical roles in the pathogenesis of common dermatoses such as acne,seborrhea,and atopic der-matitis.The endocannabinoid system(ECS)is a complex homeostatic signaling network that comprises endocannabinoids,cannabinoid receptors,and enzymes responsible for endocannabi-noid transport,synthesis,and degradation.Recent evidence has indicated the expression and functional involvement of ECS components in human SGs,suggesting the therapeutic potential of ECS modulation in the management of SG-associated diseases.This review provides an overview of research progress on the regulatory effects of ECS on SG functions.
endocannabinoid systemsebaceous glandsskin barrier function
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