The Role of Cardiac Sodium Channel Nav1.5 in Cardiac Arrhythmias
Cardiac arrhythmias are among cardiovascular diseases with high morbidity and mortal-ity rates worldwide,associated with impaired cardiac ion channel function and abnormal conduc-tion of electrophysiological signals in cardiomyocytes.The cardiac sodium channel Nav1.5 plays a crucial role in the initiation and propagation of action potentials in cardiomyocytes.Abnormal ex-pression and regulation of Nav1.5 due to gene mutations constitute a significant biological basis for the occurrence of arrhythmias.This article summarizes the structure and function of Nav1.5,as well as its relationship with cardiac arrhythmias,with the aim of providing a theoretical basis for future research and development of cardiovascular drugs,their clinical applications,and drug-induced cardiotoxicity.
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