Autophagy is a dynamic protective mechanism that degrades macromolecules and or-ganelles within cells to maintain organismal balance.Most eukaryotic cells rely on autophagy to regulate intracellular homeostasis.Under certain stress conditions,such as ischemia and hypoxi-a,autophagy exerts protective effects to counteract cellular damage.However,selective overacti-vation of autophagy can lead to a unique form of programmed cell death,distinct from apoptosis and necrosis,termed autosis.This review summarizes the distinctions between autosis and other cell death modalities,the morphological characteristics of autosis,the conditions that induce au-tosis,and current research progress on autosis,aiming to provide a theoretical basis for further research on autosis and to offer a scientific reference for subsequent studies and future clinical dis-ease treatment.
维普
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