Advances in the Study of TRPC Channels and Tumorigenesis
The incidence and mortality of various tumors have been increasing,and the search for novel anti-tumor targets is one of the major research directions for anti-tumor drug development.Transient receptor potential canonical(TRPC)channels are a class of critical non-selective cation channels permeable to sodium(Na+),calcium(Ca2+),and other cations located on the cell membrane,which are widely distributed in vivo and participate in a variety of physiological and pathological processes.Studies have shown that the protein and mRNA levels of TRPCs are ab-normally overexpressed in various tumor cells,which can promote tumor proliferation by increas-ing the intracellular Ca2+concentration of tumor cells.Since TRPC receptors are located on the cell surface,ion channel-targeted drugs do not need to enter the cell,making them ideal thera-peutic targets.Ca2+,as one of the most essential intracellular messengers,plays a critical role in regulating cell growth and death,as well as tumor cell proliferation and apoptosis.Ca2+-permea-ble TRPC channels play a crucial role in tumor development,making them prognostic markers and potential therapeutic targets for malignant tumors.Targeting TRPC channels to regulate in-tracellular Ca2+concentration and,in turn,modulate downstream signaling pathways is a novel approach to inhibiting tumor cell proliferation.This review summarizes the effects and mecha-nisms of TRPCs on tumorigenesis and development,and focuses on the potential of the extracel-lular small molecule binding pockets of the TRPC family as targets for anti-tumor small molecule compounds.
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