Parkinson's disease(PD)is a chronic,progressive neurodegenerative disorder charac-terized by classic clinical features including motor symptoms such as tremor,muscle rigidity,bradykinesia,and abnormal posture and gait,as well as a variety of non-motor symptoms.Mito-chondrial dysfunction plays a crucial role in the pathogenesis of PD,propelling genes associated with mitochondrial function to the forefront of current research endeavors.Some gene mutations are closely related to the pathogenesis of PD.Mitochondrial-related PD pathogenic genes include genes involved in mitochondrial dynamics,mitochondrial DNA homeostasis,mitochondrial pro-tein translation,the mitochondrial respiratory chain,and mitochondrial metabolism,participat-ing in the regulation of mitochondrial function and mitochondrial quality control,ultimately lead-ing to structural and functional abnormalities in mitochondria.This article provides an overview of the mitochondrial-related PD pathogenic genes that are directly or indirectly associated with the onset and development of PD.Through in-depth studies of the functions and mechanisms of these genes,it is hoped that better therapeutic methods and prevention strategies for PD can be identi-fied.
关键词
帕金森病/线粒体/致病基因/线粒体DNA
Key words
Parkinson's disease/mitochondria/pathogenic genes/mitochondrial DNA
维普
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