Research Progress on the Structure and Function of METTL8
Methyltransferase-like 8(METTL8)is a member of the methyltransferase-like protein(METTL)family,which typically utilizes S-adenosylmethionine(SAM)as a substrate to cata-lyze methylation.3-methylcytidine(m3C)is a type of methylation that occurs at the third nitro-gen atom of the cytosine base in RNA,playing a wide-ranging role in maintaining RNA secondary structure,stability,and function.METTL8 is currently the only enzyme known to regulate m3C modification in both messenger ribonucleic acid(mRNA)and transfer ribonucleic acid(tRNA).Additionally,METTL8 is closely associated with processes such as embryonic stem cell differen-tiation,skeletal muscle gene regulation,and tumor proliferation.Given the significant role of METTL8,this article focuses on the structural composition,functional characteristics,and re-search progress associated with METTL8,aiming to provide insights for further investigation in-to its biological functions.
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