Research Progress on the Mechanism by Which Magnesium Ions Promote Bone Regeneration Under Hypoxic Environment
The repair and regeneration of bone tissue defects is a complex and slow pathophysio-logical process,representing a significant challenge in oral clinical treatment.Hypoxia leads to an inadequate blood supply to injured bone tissue,significantly impairing the repair and regeneration of bone tissue defects.Magnesium and magnesium alloys,as novel types of degradable and absorb-able materials for bone tissue engineering implants,release magnesium ions under hypoxic condi-tions.These magnesium ions can activate cell signaling pathways related to hypoxia-inducible fac-tors,promoting angiogenesis,preserving the osteogenic function of bone cells,and facilitating the repair and regeneration of injured bone tissue.Accordingly,this article reviews the factors influen-cing bone tissue regeneration under hypoxic environments and current state of research on the mechanisms by which magnesium ions promote bone regeneration,aiming to lay a foundation for the subsequent development of various medical magnesium alloy biomaterials that facilitate the repair of bone tissue defects.
万方数据
维普
